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The cytomegalovirus-encoded chemokine receptor US28 promotes intestinal neoplasia in transgenic micep21 loss blocks senescence following Apc loss and provokes tumourigenesis in the renal but not the intestinal epitheliumChemoprevention by nonsteroidal anti-inflammatory drugs eliminates oncogenic intestinal stem cells via SMAC-dependent apoptosisIntestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like propertiesDevelopmental stage-specific contribution of LGR5(+) cells to basal and luminal epithelial lineages in the postnatal mammary glandLgr5 marks cycling, yet long-lived, hair follicle stem cells.Mining the Wnt pathway for cancer therapeutics.TCF: Lady Justice casting the final verdict on the outcome of Wnt signallingDll1+ secretory progenitor cells revert to stem cells upon crypt damageYou Wnt some, you lose some: oncogenes in the Wnt signaling pathway.Curr OpinConstitutive Transcriptional Activation by a beta-catenin-Tcf complex in APC-/- Colon CarcinomaIdentifying the stem cell of the intestinal crypt: strategies and pitfallsLineage tracing in the intestinal epitheliumThe Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markersLgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitroTissue-resident adult stem cell populations of rapidly self-renewing organsActomyosin-mediated cellular tension drives increased tissue stiffness and beta-catenin activation to induce epidermal hyperplasia and tumor growthSpindle orientation bias in gut epithelial stem cell compartments is lost in precancerous tissueLgr5 homologues associate with Wnt receptors and mediate R-spondin signallingThe zebrafish reference genome sequence and its relationship to the human genome.Mutant E-cadherin breast cancer cells do not display constitutive Wnt signalingCatenins, Wnt signaling and cancerSingle Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche.Cdx2 determines the fate of postnatal intestinal endodermCloning and characterization of hELD/OSA1, a novel BRG1 interacting proteinA comprehensive model of the spatio-temporal stem cell and tissue organisation in the intestinal cryptTumor environment: a potent driving force in colorectal cancer?Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skinLeucine-rich repeat-containing G-protein-coupled receptors as markers of adult stem cellsPeyer's patch M cells derived from Lgr5(+) stem cells require SpiB and are induced by RankL in cultured "miniguts"Paneth cells constitute the niche for Lgr5 stem cells in intestinal cryptsThe chromatin remodelling factor Brg-1 interacts with beta-catenin to promote target gene activationLgr5(+ve) stem/progenitor cells contribute to nephron formation during kidney developmentActivation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APCThe intestinal stem cell.The role of APC and beta-catenin in the aetiology of aggressive fibromatosis (desmoid tumors)WNT signaling in the normal intestine and colorectal cancerCrypt stem cells as the cells-of-origin of intestinal cancer.Transcription factor achaete scute-like 2 controls intestinal stem cell fate.Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells
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Publiek - Geen beperking
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