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Long-term proteasome dysfunction in the mouse brain by expression of aberrant ubiquitin.Intermediate filament transcription in astrocytes is repressed by proteasome inhibition.Impairment of the tRNA-splicing endonuclease subunit 54 (tsen54) gene causes neurological abnormalities and larval death in zebrafish models of pontocerebellar hypoplasiaAlzheimer-associated mutant ubiquitin impairs spatial reference memory.A star is bornThe effect of mutant ubiquitin on proteasome function in relation to neurodegenerative disease.Silencing GFAP isoforms in astrocytoma cells disturbs laminin-dependent motility and cell adhesionMutant ubiquitin decreases amyloid beta plaque formation in a transgenic mouse model of Alzheimer's disease.Wnt signaling in Alzheimer's disease: up or down, that is the questionModest proteasomal inhibition by aberrant ubiquitin exacerbates aggregate formation in a Huntington disease mouse model.Presenilin mouse and zebrafish models for dementia: focus on neurogenesis.Histone acetylation in astrocytes suppresses GFAP and stimulates a reorganization of the intermediate filament networkasb11 is a regulator of embryonic and adult regenerative myogenesisLow levels of mutant ubiquitin are degraded by the proteasome in vivo.
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P. van Tijn
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Public - No restriction
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Publiek - Geen beperking
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drs.
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