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Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progenyLong-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epitheliumOral mucosal organoids as a potential platform for personalized cancer therapyCCBE1 is essential for mammalian lymphatic vascular development and enhances the lymphangiogenic effect of vascular endothelial growth factor-C in vivoTroy+ brain stem cells cycle through quiescence and regulate their number by sensing niche occupancyIntestinal stem cells lacking the Math1 tumour suppressor are refractory to Notch inhibitorsEnteroendocrine cells switch hormone expression along the crypt-to-villus BMP signalling gradientLgr5 marks cycling, yet long-lived, hair follicle stem cells.Dll1+ secretory progenitor cells revert to stem cells upon crypt damageDistinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epitheliumThe BMP antagonist follistatin-like 1 is required for skeletal and lung organogenesisThe Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markersPorcupine inhibitor suppresses paracrine Wnt-driven growth of Rnf43;Znrf3-mutant neoplasiaProbing the Tumor Suppressor Function of BAP1 in CRISPR-Engineered Human Liver OrganoidsUnbiased transcription factor CRISPR screen identifies ZNF800 as master repressor of enteroendocrine differentiationLgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitroPaneth cellsA20 controls intestinal homeostasis through cell-specific activitiesBiased competition between Lgr5 intestinal stem cells driven by oncogenic mutation induces clonal expansionLgr5 homologues associate with Wnt receptors and mediate R-spondin signallingNotch ligand Dll1 mediates cross-talk between mammary stem cells and the macrophageal nicheSingle Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche.Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epitheliumInvestigation of Frizzled-5 during embryonic neural development in mouse.Generation of an inducible colon-specific Cre enzyme mouse line for colon cancer researchLineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomasReg4+ deep crypt secretory cells function as epithelial niche for Lgr5+ stem cells in colonHDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interactionGeneration and analysis of mouse intestinal tumors and organoids harboring APC and K-Ras mutationsMule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal DegradationSingle-molecule transcript counting of stem-cell markers in the mouse intestineControlled gene expression in primary Lgr5 organoid culturesEnteroendocrine and tuft cells support Lgr5 stem cells on Paneth cell depletionReplacement of Lost Lgr5-Positive Stem Cells through Plasticity of Their Enterocyte-Lineage DaughtersLgr6 marks stem cells in the hair follicle that generate all cell lineages of the skinPaneth cells constitute the niche for Lgr5 stem cells in intestinal cryptsUnlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axisGRASP65 controls the cis Golgi integrity in vivoLgr5(+ve) stem/progenitor cells contribute to nephron formation during kidney developmentDNA methylation dynamics during intestinal stem cell differentiation reveals enhancers driving gene expression in the villus
author
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J.H. van Es
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Public - No restriction
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Publiek - Geen beperking
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dr.
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