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agent
Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progenyProspective derivation of a living organoid biobank of colorectal cancer patientsHuman tissues in a dishDesigner matrices for intestinal stem cell and organoid cultureOrigins of lymphatic and distant metastases in human colorectal cancerUse of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancerCharacterizing responses to CFTR-modulating drugs using rectal organoids derived from subjects with cystic fibrosisTargeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screeningLoss of the Wnt receptor frizzled 7 in the mouse gastric epithelium is deleterious and triggers rapid repopulation in vivoDiscovery of molecular markers to discriminate corneal endothelial cells in the human bodyIntegrated genome-wide analysis of transcription factor occupancy, RNA polymerase II binding and steady-state RNA levels identify differentially regulated functional gene classesThe Wnt PathwayThe intestinal crypt, a prototype stem cell compartmentThe SRY-HMG box gene, SOX4, is a target of gene amplification at chromosome 6p in lung cancerReuniting philosophy and science to advance cancer researchThoughts on thymus and T-lymphocyte repertoire. Relevance to the tolerance of the immune responseA promoter-level mammalian expression atlasWNT signalling events near the cell membrane and their pharmacological targeting for the treatment of cancerHydrogel-in-hydrogel live bioprinting for guidance and control of organoids and organotypic culturesSequence-specific high mobility group box factors recognize 10-12-base pair minor groove motifsCaught up in a Wnt storm: Wnt signaling in cancerStrategies for homeostatic stem cell self-renewal in adult tissuesEstablishment of human fetal hepatocyte organoids and CRISPR-Cas9-based gene knockin and knockout in organoid cultures from human liverStem cells marked by the R-spondin receptor LGR5Self-renewal and cancer of the gut: two sides of a coin.Erk and MAPK signaling is essential for intestinal development through Wnt pathway modulationLong-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epitheliumThe cytomegalovirus-encoded chemokine receptor US28 promotes intestinal neoplasia in transgenic miceMutations in the APC tumor suppressor gene cause chromosomal instability in colorectal cancerToepassingen van levende biobank zijn grenzeloosBeta- catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinBThe R-spondin/Lgr5/Rnf43 moduleRegulation of stem cell therapies under attack in Europe: for whom the bell tollsRetinoic acid-induced pancreatic stellate cell quiescence reduces paracrine Wnt-beta-catenin signaling to slow tumor progressionp21 loss blocks senescence following Apc loss and provokes tumourigenesis in the renal but not the intestinal epitheliumThe human Tcf-1 gene encodes a nuclear DNA-binding protein, uniquely expressed in normal and neoplastic T lineage lymphocytesSequencing metabolically labeled transcripts in single cells reveals mRNA turnover strategiesWnt/beta-catenin signaling and diseaseOral mucosal organoids as a potential platform for personalized cancer therapyForskolin-induced Swelling in Intestinal Organoids
author
education
type
label
J.C. Clevers
firstName
lastName
name
employeeId
orcid
0000-0002-3077-5582
about
<p>Hans Clevers obtained his M ...... therlands Lion since 2012.</p>
@en
researchinterests
<p>Hans Clevers obtained his M ...... therlands Lion since 2012.</p>
@en
orcid
workforce_id
staffOrganisationAssociations
supervisorForRelations
visibility
Public - No restriction
@en
Publiek - Geen beperking
@nl
relatedLink
title
prof. dr.
@en