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Immune-evasive gene switch enables regulated delivery of chondroitinase after spinal cord injury.Timed GDNF gene therapy using an immune-evasive gene switch promotes long distance axon regeneration.Purification of recombinant adeno-associated virus by iodixanol gradient ultracentrifugation allows rapid and reproducible preparation of vector stocks for gene transfer in the nervous systemOptimization of adeno-associated viral vector-mediated transduction of the corticospinal tractLong-term adeno-associated viral vector-mediated expression of truncated TrkB in the adult rat facial nucleus results in motor neuron degenerationTransient downregulation of Sema3A mRNA in a rat model for temporal lobe epilepsy. A novel molecular event potentially contributing to mossy fiber sproutingThe Jun-dependent axon regeneration gene programSemaphorin IIIAdenoviral vector-mediated gene expression in the nervous system of immunocompetent Wistar and T cell-deficient nude ratsThe role of the neural growth associated protein B-50/GAP-43 in morphogenesisAAV vector-mediated secretion of chondroitinase provides a sensitive tracer for axonal arborisationsA gene network perspective on axonal regeneration.Expression of the gene encoding the chemorepellent semaphorin III is induced in the fibroblast component of neural scar tissue formed following injuries of adult but not neonatal CNSViral vector-mediated gene expression in olfactory ensheathing glia implants in the lesioned rat spinal cordDifferential effects of lentiviral vector-mediated overexpression of nerve growth factor and glial cell line-derived neurotrophic factor on regenerating sensory and motor axons in the transected peripheral nerveIntercostal nerve implants transduced with an adenoviral vector encoding neurotrophin-3 promote regrowth of injured rat corticospinal tract fibers and improve hindlimb functionThe use of adenoviral vectors and ex vivo transduced neurotransplantsSulfatase-mediated manipulation of the astrocyte-Schwann cell interfaceIdentification of candidate transcriptional modulators involved in successful regeneration after nerve injuryTargeted overexpression of the neurite growth-associated protein B-50/GAP-43 in cerebellar Purkinje cells induces sprouting after axotomy but not axon regeneration into growth-permissive transplantsAdenoviral vector-directed expression of neurotrophin-3 in rat dorsal root ganglion explants results in a robust neurite outgrowth responseVision on gyrate atrophyLentiviral-mediated expression of polysialic acid in spinal cord and conditioning lesion promote regeneration of sensory axons into spinal cordDeveloping a potentially immunologically inert tetracycline-regulatable viral vector for gene therapy in the peripheral nerveViral vectors, tools for gene transfer in the nervous systemEx vivo adenoviral vector-mediated neurotrophin gene transfer to olfactory ensheathing gliaTranscriptome analysis of normal-appearing white matter reveals cortisol- and disease-associated gene expression profiles in multiple sclerosisNeurotrophin receptors in Alzheimer's diseaseClinical and neurobiological advances in promoting regeneration of the ventral root avulsion lesionChondroitinase ABC promotes plasticity of spinal reflexes following peripheral nerve injury.Adeno-associated viral vector-mediated gene transfer of brain-derived neurotrophic factor reverses atrophy of rubrospinal neurons following both acute and chronic spinal cord injuryGene transfer to the spinal cord neural scar with lentiviral vectorsEnhanced regeneration and reinnervation following timed GDNF gene therapy in a cervical ventral root avulsionIntrinsic Determinants of Axon RegenerationNerve surgery and gene therapy: a neurobiological and clinical perspective.The astrocyte/meningeal cell interface is a barrier to neurite outgrowth which can be overcome by manipulation of inhibitory molecules or axonal signalling pathwaysCERTL reduces C16 ceramide, amyloid-β levels, and inflammation in a model of Alzheimer's diseaseA novel peptidomics approach to detect markers in cerebrospinal fluid of Alzheimer's disease samples.LLM3D: a log-linear modeling-based method to predict functional gene regulatory interactions from genome-wide expression data.Neurotrophic ACTH4-9 analogue therapy normalizes electroencephalographic alterations in chronic experimental allergic encephalomyelitis
author
education
type
label
J. Verhaagen
firstName
lastName
name
employeeId
orcid
0000-0002-8341-1096
orcid
workforce_id
staffOrganisationAssociations
visibility
Public - No restriction
@en
Publiek - Geen beperking
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relatedLink
title
prof. dr.
@en