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Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epitheliumTroy+ brain stem cells cycle through quiescence and regulate their number by sensing niche occupancyDefining and Mining the Intestinal Stem Cell SignatureFrizzled7 functions as a wnt receptor in intestinal epithelial lgr5(+) stem cellsThe ets-domain transcription factor Spdef promotes maturation of goblet and paneth cells in the intestinal epithelium.The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markersLrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signallingLgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitroLgr5 homologues associate with Wnt receptors and mediate R-spondin signallingSingle Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche.Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epitheliumLineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomasOLFM4 is a robust marker for stem cells in human intestine and marks a subset of colorectal cancer cells.Controlled gene expression in primary Lgr5 organoid culturesLgr6 marks stem cells in the hair follicle that generate all cell lineages of the skinPaneth cells constitute the niche for Lgr5 stem cells in intestinal cryptsIndian hedgehog regulates intestinal stem cell fate through epithelial-mesenchymal interactions during developmentTranscription factor achaete scute-like 2 controls intestinal stem cell fate.Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptorsHighly sensitive proteome analysis of FACS-sorted adult colon stem cellsDefining the Identity and Dynamics of Adult Gastric Isthmus Stem CellsProminin-1/CD133 marks stem cells and early progenitors in mouse small intestine.Concise review: the yin and yang of intestinal (cancer) stem cells and their progenitors
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D.E. Stange
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Public - No restriction
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Publiek - Geen beperking
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