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Protein O-Glucosyltransferase 1 (POGLUT1) Promotes Mouse Gastrulation through Modification of the Apical Polarity Protein CRUMBS2Recombinant Adeno-Associated Viral Vectors (rAAV)-Vector Elements in Ocular Gene Therapy Clinical Trials and Transgene Expression and Bioactivity AssaysTargeted ablation of Crb1 and Crb2 in retinal progenitor cells mimics Leber Congenital Amaurosis.AAV Gene Augmentation Therapy for CRB1-Associated Retinitis PigmentosaDefining phenotype, tropism, and retinal gene therapy using adeno-associated viral vectors (AAVs) in new-born brown norway rats with a spontaneous mutation in CRB1Pseudoxantoma Elasticum: A clinical, histopathological and molecular updateContribution of the drug transporter ABCG2 (breast cancer resistance protein) to resistance against anticancer nucleosides.CRB2 Loss in Rod Photoreceptors Is Associated with Progressive Loss of Retinal Contrast SensitivityPSD95beta regulates plasma membrane Ca(2+) pump localization at the photoreceptor synapse.The apical complex couples cell fate and cell survival to cerebral cortical development.Gene therapy into photoreceptors and Müller glial cells restores retinal structure and function in CRB1 retinitis pigmentosa mouse modelsCrumbs2 mediates ventricular layer remodelling to form the spinal cord central canalTMEM16B, a novel protein with calcium-dependent chloride channel activity, associates with a presynaptic protein complex in photoreceptor terminals.CRB2 in immature photoreceptors determines the superior-inferior symmetry of the developing retina to maintain retinal structure and functionProduction of iPS-Derived Human Retinal Organoids for Use in Transgene Expression AssaysA New CRB1 Rat Mutation Links Müller Glial Cells to Retinal TelangiectasiamRNA trans-splicing dual AAV vectors for (epi)genome editing and gene therapyMicroarray and morphological analysis of early postnatal CRB2 mutant retinas on a pure C57BL/6J genetic background.Clinical characteristics and natural history of rho-associated retinitis pigmentosa.Crumbs2 Is an Essential Slit Diaphragm Protein of the Renal Filtration BarrierABCC6/MRP6 mutations: further insight into the molecular pathology of pseudoxanthoma elasticumResearch models and gene augmentation therapy for CRB1 retinal dystrophies.MPP3 regulates levels of PALS1 and adhesion betweenphotoreceptors and Muller cells.CLINICAL AND GENETIC CHARACTERISTICS OF MALE PATIENTS WITH RPGR-ASSOCIATED RETINAL DYSTROPHIESBone spicule pigment formation in retinitis pigmentosa: insights from a mouse model.Specific tools for targeting and expression in Müller glial cellsLoss of CRB2 in the mouse retina mimics human retinitis pigmentosa due to mutations in the CRB1 gene.Novel Therapeutic Approaches for the Treatment of Retinal Degenerative DiseasesCharacterization and AAV-mediated CRB gene augmentation in human-derived CRB1KO and CRB1KOCRB2+/- retinal organoidsThe CRB1 Complex: Following the Trail of Crumbs to a Feasible Gene Therapy StrategyCRB1-associated retinal dystrophiesHuman iPSC-Derived Retinas Recapitulate the Fetal CRB1 CRB2 Complex Formation and Demonstrate that Photoreceptors and Müller Glia Are Targets of AAV5"Basal Cell Migration" in Regeneration of the Corneal Wound-BedMPP3 is required for maintenance of the apical junctional complex, neuronal migration and stratification in the developing cortex.AAV-CRB2 protects against vision loss in an inducible CRB1 retinitis pigmentosa mouse modelMicroglial Cell Dysfunction in CRB1-Associated RetinopathiesRetinal Ciliopathies and Potential Gene TherapiesCRB1 is required for recycling by RAB11A+ vesicles in human retinal organoidsGFAP-driven GFP expression in activated mouse Muller glial cells aligning retinal blood vessels following intravitreal injection of AAV2/6 vectors.Genetic and Molecular Approaches to Study Neuronal Migration in the Developing Cerebral Cortex
author
education
type
label
J. Wijnholds
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lastName
name
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visibility
Public - No restriction
@en
Publiek - Geen beperking
@nl
relatedLink
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dr.
@en