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Next generation sequencing of triple negative breast cancer to find predictors for chemotherapy responseNatural variation of histone modification and its impact on gene expression in the rat genomeUse of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancerTranslational regulation shapes the molecular landscape of complex disease phenotypesIntegrated genome-wide analysis of transcription factor occupancy, RNA polymerase II binding and steady-state RNA levels identify differentially regulated functional gene classesMismatch repair deficiency does not enhance ENU mutagenesis in the zebrafish germ line.DNA isolation from rat tail or earHomozygous and heterozygous p53 knockout rats develop metastasizing sarcomas with high frequencyZebrafish with mutations in mismatch repair genes develop neurofibromas and other tumors.SambambaHigh-throughput semiquantitative analysis of insertional mutations in heterogeneous tumorsPDZ motifs in PTP-BL and RIL bind to internal protein segments in the LIM domain protein RILThe G-protein beta-subunit GPB-2 in Caenorhabditis elegans regulates the G(o)alpha-G(q)alpha signaling network through interactions with the regulator of G-protein signaling proteins EGL-10 and EAT-16Chromothripsis is a common mechanism driving genomic rearrangements in primary and metastatic colorectal cancerHigh-throughput target-selected gene inactivation in zebrafishGenomic DNA pooling strategy for next-generation sequencing-based rare variant discovery in abdominal aortic aneurysm regions of interest-challenges and limitationsSequential cancer mutations in cultured human intestinal stem cellsMicroalterations of inherently unstable genomic regions in rat mammary carcinomas as revealed by long oligonucleotide array-based comparative genomic hybridizationGenomic and Functional Overlap between Somatic and Germline Chromosomal RearrangementsReduced rates of gene loss, gene silencing, and gene mutation in Dnmt1-deficient embryonic stem cellsProgress and prospects in rat genetics: a community view.Serotonin transporter null mutation and sexual behavior in female rats: 5-HT1A receptor desensitizationLack of Major Genome Instability in Tumors of p53 Null RatsA novel Caenorhabditis elegans allele, smn-1(cb131), mimicking a mild form of spinal muscular atrophy, provides a convenient drug screening platform highlighting new and pre-approved compoundsThe serotonin transporter plays an important role in male sexual behavior: a study in serotonin transporter knockout ratsCompletion of meiosis in male zebrafish (Danio rerio) despite lack of DNA mismatch repair gene mlh1.Cloning and expression of new microRNAs from zebrafishA Living Biobank of Breast Cancer Organoids Captures Disease HeterogeneityChromothripsis as a mechanism driving complex de novo structural rearrangements in the germlineCell autonomous lipin 1 function is essential for development and maintenance of white and brown adipose tissueWnt-induced transcriptional activation is exclusively mediated by TCF/LEFIncomplete segregation of MYH11 variants with thoracic aortic aneurysms and dissections and patent ductus arteriosusToward effective software solutions for big biologySARS-CoV-2 productively infects human gut enterocytesA FERM domain governs apical confinement of PTP-BL in epithelial cellsE2F7 represses a network of oscillating cell cycle genes to control S-phase progressionLong-term expanding human airway organoids for disease modelingHet gaat om de output, niet om de urenGenome-wide analysis of FOXO3 mediated transcription regulation through RNA polymerase II profilingApproaches to microRNA discovery
author
type
label
Edwin Cuppen
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lastName
name
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employeeEndDate
2015-10-01T12:00:00.000+0000
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2000-03-01T12:00:00.000+0000
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0000-0002-0400-9542
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visibility
Public - No restriction
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Publiek - Geen beperking
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relatedLink
title
prof. dr. ir.
@en