Hubrecht Institute for Developmental Biology and Stem Cell Research
Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progenyProspective derivation of a living organoid biobank of colorectal cancer patientsHuman tissues in a dishDesigner matrices for intestinal stem cell and organoid cultureNext generation sequencing of triple negative breast cancer to find predictors for chemotherapy responseNatural variation of histone modification and its impact on gene expression in the rat genomeOrigins of lymphatic and distant metastases in human colorectal cancerUse of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancerCharacterizing responses to CFTR-modulating drugs using rectal organoids derived from subjects with cystic fibrosisTargeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screeningTranslational regulation shapes the molecular landscape of complex disease phenotypesLoss of the Wnt receptor frizzled 7 in the mouse gastric epithelium is deleterious and triggers rapid repopulation in vivoCold Spring Harbor meeting on Eukaryotic DNA Replication & Genome MaintenanceCGDB Graduate Zebrafish Course, UtrechtInvited TalkMeet the professor[Presentation]Small RNA BiologyFishing for genes related to congenital heart defectsIn PhD supervisory committee of 12 PhD studentsForce dependent localization of VASP and Zyxin at Cadherin junctions’Islet Cell TransplantationNovel therapeutic approaches in the infertility clinicUbiquitin ligases and cancerMorphogenesis of axial tissues in the mouse embryoVertebrate vasculogenesis and (lymph) angiogenesisDevelopmental Biology (Journal)Dazl'in Germ CellsIn examination committee of 8 PhD studentsControlling gene expression fluctuations during developmentInvited talkThe 18th International, Genetic Systems in the RatStichting Vrienden van het Hubrecht InstituutNIPD progressDutch meeting on cardiac developmentWnt signaling, Lgr5 stem cells and cancerWnt signaling, Lgr5 stem cells and cancerThe zebrafish full-of-fluid mutant identifies a secreted protein essential for lymphangiogenesis in zebrafish and humansGenetic basis of axial development in the mouseUnraveling viral infection heterogeneity using single-molecule imaging
managingOrganisationalUnit
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organisationalUnit
Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progenyProspective derivation of a living organoid biobank of colorectal cancer patientsHuman tissues in a dishDesigner matrices for intestinal stem cell and organoid cultureNext generation sequencing of triple negative breast cancer to find predictors for chemotherapy responseNatural variation of histone modification and its impact on gene expression in the rat genomeOrigins of lymphatic and distant metastases in human colorectal cancerUse of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancerCharacterizing responses to CFTR-modulating drugs using rectal organoids derived from subjects with cystic fibrosisTargeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screeningTranslational regulation shapes the molecular landscape of complex disease phenotypesLoss of the Wnt receptor frizzled 7 in the mouse gastric epithelium is deleterious and triggers rapid repopulation in vivo012088667ef240c58d6cc6a10f79d14c01edd7243aa04eb8848055ec5a9d15c5028d302250fd41d3bd461188b652ab1705998de614de405e91456dcd38942ae90789d1df13ff40d992eb598a99069ec908d47275c5e44c6eb67fafd9ff88f3fa096f903ae9444c64a2c31eb8efbc54a4098ab727181d4a7fbe07fed6cb26ee5f098ef25a1f004f29b017bd5716065e1309c4c947817f4760ab26f20ce1623e5a0aabac8a89764844baf753941582a7700b6cc6951de54ed5821c2f27f2f85e1c0bb383ed9da34d56bb713fd9835a5f260caa4041dee34e57a1cc9bd6bc66b1390e64d93b72514f7e8cd4000bfb0a8d5d0f34b5ca987c481792fca98061d87b260fa39ae71a8442779844f0d2dd364c610fa9bc8ffd7e4a9c87c4babd5aa11f351027198d65694753b0082a6b7be95d711027420ad739486fb4a8f05efc1d93c41057d40e33aa4ef4b77c4914a1cb0da010637a461c1d41ebb4a94717fb1d71e5106f5099dcb049cf8d3a187b04cc303610c1e6053a9745b9a4e9853ca4c894e6112d56e62c8340999df135ae82d0e70b11bc2fcd0fa545b78ad74b73adadcc5e129b61429d154c64bd312a9530a9db9c13dc4a68d5bd4105a1a2fc35ef665d3a
organisationalUnits
Cell-intrinsic and -extrinsic regulation of developmental hematopoiesisSMArt CRISPRProtective and pathological remodeling in cardiac diseaseOrganoid technology as an emerging tool for gynecological oncology research: Dawn of precision medicine in cancer researchUncovering the molecular mechanisms underlying arrhythmogenic cardiomyopathy using the CRISPR-toolboxBIG DATA to understand BIG HEARTS: Unravelling the molecular mechanisms in hypertrophic cardiomyopathyFactors shaping the 3D genomeIntracranial aneurysms : (epi)genetic and pathogenic factors in the circle of WillisFinding the way: transcriptional regulation of migratory neuroblast lineages in C. elegansInterplay of PTEN subcellular localization and catalytic activities in vivoOrganoids as a tool for fundamental and translational oncology research : Can organoids guide clinical decision making?Uncovering the road towards cardiomyocyte proliferation: Temporal and spatial analysis of heart regeneration in zebrafishFactors involved in cardiac physiological and pathological remodelingConstructing roadmaps towards functional cell types using organoids: Shaping and changing the functions of the intestineCRISPR engineering in organoids for gene repair and disease modelingPlasticity of intestinal epithelial cells in regeneration and cancerModeling human cardiac genetic diseases in the zebrafish: Focus on cardiomyopathies and cohesinopathiesThe Many Faces of Gene Regulation: Extrinsic Control of Cell Fate and FunctionLessons from the zebrafish: How to regenerate a heartDecrypting gastrointestinal development and homeostasis one cell at a timeCdx2 is essential for embryonic axial growth and identity of the adult intestinal stem cellsOrigins and divergence of the eukaryotic kinetochoreIntravital imaging of cancer : visualizing the bad guysNot All Chromosomes Are Created Equal: Following individual chromosomes in mitosis and beyondGene Control in 3D : The Roles of CTCF and Chromatin Looping in Organizing a Functional GenomeVisualizing mRNA quality control: Mechanistic insights from translational dynamicsGene expression in sight: Single-molecule studies of gene expression controlFrom stresses satellite cells to mouse and human gastruloids. Applications of single-cell and spatial transcriptomicsThe DUX4 cytotoxic cascade, and CRISPR mitigation methodsUnraveling the mechano-responsive mechanisms at Focal Adherens JunctionsContactomics - exploring new dimensions of 3D genome architectureMouse Hox and Cdx genes: Early regulation and involvement on embryonic axial extensionA tale of two measurements: protein-DNA interactions and gene expression in single cells. Protein-DNA interactions and gene expression in single cellsMosaic Variegated Aneuploidy: Elucidating the molecular causes of constitutional aneuploidy in humansSlamf receptorsCis-regulatory elements in the primate brain: from functional specialization to neurodegenerationRegulation of Wat signal transductionHematopoiesis in the developing zebrafish embryoEvolution of the Kinetochore Network in EukaryotesFishing for genes : Using zebrafish to study the functional genetics of cardiac arrhythmias
supervisorOrganisationalUnits
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sponsor
Hubrecht Institute for Developmental Biology and Stem Cell Research
type
label
Hubrecht Institute for Developmental Biology and Stem Cell Research
@en
Hubrecht Instituut voor Ontwikkelingsbiologie en Stamcelonderzoek
@nl
communication@hubrecht.eu
requestforcopy
secretary@hubrecht.eu
phone
+31 (0)30 212 1800
grid_id
grid.419927.0
isni
0000 0000 9471 3191
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organisationid
https://ror.org/023qc4a07
scopus_affiliation_id
name
Hubrecht Institute for Developmental Biology and Stem Cell Research
@en
Hubrecht Instituut voor Ontwikkelingsbiologie en Stamcelonderzoek
@nl
visibility
Public - No restriction
@en
Publiek - Geen beperking
@nl