b54c7063-ee8c-4be2-bbbd-e1d1930f674d
Celebrating 100 years of Developmental Biology at the Hubrecht InstituteTargeting Oncogenic Src Homology 2 Domain-Containing Phosphatase 2 (SHP2) by Inhibiting Its Protein-Protein InteractionsGregatins, a Group of Related Fungal Secondary Metabolites, Inhibit Aspects of Quorum Sensing in Gram-Negative BacteriaEvolution-Informed Discovery of the Naphthalenone Biosynthetic Pathway in FungiPten mediates Myc oncogene dependence in a conditional zebrafish model of T cell acute lymphoblastic leukemiaPhosphoproteomics-mediated identification of Fer kinase as a target of mutant Shp2 in Noonan and LEOPARD syndromeLoss of Shp1 impairs myeloid cell function and causes lethal inflammation in zebrafish larvaeA versatile spectrophotometric protein tyrosine phosphatase assay based on 3-nitrophosphotyrosine containing substratesRedox regulation of dimerization of the receptor protein-tyrosine phosphatases RPTPalpha, LAR, RPTPmu and CD45.Receptor protein tyrosine phosphatase alpha enhances rheumatoid synovial fibroblast signaling and promotes arthritis in miceA unified nomenclature and amino acid numbering for human PTENA variant in the carboxyl-terminus of connexin 40 alters GAP junctions and increases risk for tetralogy of FallotDifferential oxidation of protein-tyrosine phosphatases during zebrafish caudal fin regenerationProtein tyrosine phosphatase structure-function relationships in regulation and pathogenesisA Nodal-independent and tissue-intrinsic mechanism controls heart-looping chiralityThe receptor protein-tyrosine phosphatase, Dep1, acts in arterial/venous cell fate decisions in zebrafish developmentClassification of antimicrobial mechanism of action using dynamic bacterial morphology imagingCelebrating 100 years of Developmental Biology at the Hubrecht InstituteBerkchaetoazaphilone B has antimicrobial activity and affects energy metabolismFine-Tuning of Pten Localization and Phosphatase Activity Is Essential for Zebrafish AngiogenesisInflammatory response in hematopoietic stem and progenitor cells triggered by activating SHP2 mutations evokes blood defectsNoonan and LEOPARD syndrome Shp2 variants induce heart displacement defects in zebrafishExpanding the molecular spectrum of pathogenic SHOC2 variants underlying Mazzanti syndromeProtein tyrosine phosphatases in health and diseaseIntegrating chemical and genetic silencing strategies to identify host kinase-phosphatase inhibitor networks that control bacterial infectionAssessment of PTEN tumor suppressor activity in nonmammalian models: the year of the yeast.Phosphatidylinositol-3 kinase signaling controls survival and stemness of hematopoietic stem and progenitor cellsFerruginol suppresses survival signaling pathways in androgen-independent human prostate cancer cells.Impaired caudal fin-fold regeneration in zebrafish deficient for the tumor suppressor PtenLoss of Pten promotes angiogenesis and enhanced vegfaa expression in zebrafishZebrafish and phosphatase functionProtein tyrosine phosphatases ε and α perform nonredundant roles in osteoclastsStudying Protein-Tyrosine Phosphatases in ZebrafishDistinct and overlapping functions of ptpn11 genes in Zebrafish developmentKnocking down low molecular weight protein tyrosine phosphatase (LMW-PTP) reverts chemoresistance through inactivation of Src and Bcr-Abl proteinsNoonan syndrome gain-of-function mutations in NRAS cause zebrafish gastrulation defectsCercosporamide inhibits bone morphogenetic protein receptor type I kinase activity in zebrafishPair-wise regulation of convergence and extension cell movements by four phosphatases via RhoAPten function in zebrafishModeling (not so) rare developmental disorders associated with mutations in the protein-tyrosine phosphatase SHP2