7f2ea4e9-9c67-43a9-911e-70c3710cb434
Long-term proteasome dysfunction in the mouse brain by expression of aberrant ubiquitin.Expression of Mutant Ubiquitin and Proteostasis Impairment in Kii Amyotrophic Lateral Sclerosis/Parkinsonism-Dementia Complex BrainsAlzheimer-associated mutant ubiquitin impairs spatial reference memory.Adenoviral vector-mediated expression of B-50/GAP-43 induces alterations in the membrane organization of olfactory axon terminals in vivoUbiquitin over-expression phenottypes and ubiquitin gene molecular misreading during aging in Drosophila melanogaster.Mutant ubiquitin decreases amyloid beta plaque formation in a transgenic mouse model of Alzheimer's disease.Modest proteasomal inhibition by aberrant ubiquitin exacerbates aggregate formation in a Huntington disease mouse model.Mutant ubiquitin expressed in Alzheimer's disease causes neuronal deathActivation of the Unfolded Protein Response and Proteostasis Disturbance in Parkinsonism-Dementia of GuamLow levels of mutant ubiquitin are degraded by the proteasome in vivo.