6f6cca7b-4fa7-47ad-a399-c4502a39640c
Prospective derivation of a living organoid biobank of colorectal cancer patientsOrigins of lymphatic and distant metastases in human colorectal cancerTargeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screeningDiscovery of molecular markers to discriminate corneal endothelial cells in the human bodyFunctional patient-derived organoid screenings identify MCLA-158 as a therapeutic EGFR × LGR5 bispecific antibody with efficacy in epithelial tumorsTroy+ brain stem cells cycle through quiescence and regulate their number by sensing niche occupancySequential cancer mutations in cultured human intestinal stem cellsStem cell CD44v isoforms promote intestinal cancer formation in Apc(min) mice downstream of Wnt signalingIdentification of primary MAFB target genes in multiple myelomaIntra-tumour diversification in colorectal cancer at the single-cell levelSingle-cell dissection of transcriptional heterogeneity in human colon tumorsUnbiased transcription factor CRISPR screen identifies ZNF800 as master repressor of enteroendocrine differentiationLgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitroPreserved genetic diversity in organoids cultured from biopsies of human colorectal cancer metastasesMany novel mammalian microRNA candidates identified by extensive cloning and RAKE analysisXenograft and organoid model systems in cancer researchLgr5 homologues associate with Wnt receptors and mediate R-spondin signallingSingle Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche.Tissue-specific mutation accumulation in human adult stem cells during lifeOLFM4 is a robust marker for stem cells in human intestine and marks a subset of colorectal cancer cells.MET Signaling Mediates Intestinal Crypt-Villus Development, Regeneration, and Adenoma Formation and Is Promoted by Stem Cell CD44 IsoformsThe Constrained Maximal Expression Level Owing to Haploidy Shapes Gene Content on the Mammalian X ChromosomeAtypical teratoid/rhabdoid tumoroids reveal subgroup-specific drug vulnerabilitiesEnteroendocrine and tuft cells support Lgr5 stem cells on Paneth cell depletionLgr6 marks stem cells in the hair follicle that generate all cell lineages of the skinPaneth cells constitute the niche for Lgr5 stem cells in intestinal cryptsEWSR1-WT1 Target Genes and Therapeutic Options Identified in a Novel DSRCT In Vitro ModelEwing Sarcoma Single-cell Transcriptome Analysis Reveals Functionally Impaired Antigen-presenting CellsThe intestinal stem cell.Efficient double fragmentation ChIP-seq provides nucleotide resolution protein-DNA binding profilesCrypt stem cells as the cells-of-origin of intestinal cancer.Transcription factor achaete scute-like 2 controls intestinal stem cell fate.Highly sensitive proteome analysis of FACS-sorted adult colon stem cellsPersonalized Proteome Profiles of Healthy and Tumor Human Colon Organoids Reveal Both Individual Diversity and Basic Features of Colorectal CancerApplication of Gene Expression Trajectories Initiated from ErbB Receptor Activation Highlights the Dynamics of Divergent Promoter UsageGenome-wide pattern of TCF7L2/TCF4 chromatin occupancy in colorectal cancer cells.Ongoing chromosomal instability and karyotype evolution in human colorectal cancer organoidsSingle-cell atlas of developing murine adrenal gland reveals relation of Schwann cell precursor signature to neuroblastoma phenotypeLgr5 intestinal stem cells have high telomerase activity and randomly segregate their chromosomesFANTOM5 CAGE profiles of human and mouse samples