5a516223-5518-4535-ba9a-335211d5fdd2
Chromothripsis is a common mechanism driving genomic rearrangements in primary and metastatic colorectal cancerMicroalterations of inherently unstable genomic regions in rat mammary carcinomas as revealed by long oligonucleotide array-based comparative genomic hybridizationChromothripsis as a mechanism driving complex de novo structural rearrangements in the germlineThe genome sequence of the spontaneously hypertensive rat: Analysis and functional significanceGeneration of gene knockouts and mutant models in the laboratory rat by ENU-driven target-selected mutagenesisGenetic basis of transcriptome differences between the founder strains of the rat HXB/BXH recombinant inbred panelMany novel mammalian microRNA candidates identified by extensive cloning and RAKE analysisImproved generation of rat gene knockouts by target-selected mutagenesis in mismatch repair-deficient animals.Phylogenetic shadowing and computational identification of human microRNA genesCONREAL web server: identification and visualization of conserved transcription factor binding sitesGenome sequencing reveals loci under artificial selection that underlie disease phenotypes in the laboratory ratDominant-negative ALK2 allele associates with congenital heart defects.Accurate SNP and mutation detection by targeted custom microarray-based genomic enrichment of short-fragment sequencing librariesCASCAD: a database of annotated candidate single nucleotide polymorphisms associated with expressed sequencesAn ENU-mutagenesis screen in the mouse: identification of novel developmental gene functionsSNP and haplotype mapping for genetic analysis in the rat.Genetic variation in the zebrafishCONREAL: conserved regulatory elements anchored alignment algorithm for identification of transcription factor binding sites by phylogenetic footprintingEfficient single nucleotide polymorphism discovery in laboratory rat strains using wild rat-derived SNP candidatesDistribution and functional impact of DNA copy number variation in the rat.A novel mutant allele of Ncx1: a single amino acid substitution leads to cardiac dysfunctionSingle nucleotide polymorphism (SNP) panels for rapid positional cloning in zebrafishSingle nucleotide polymorphisms associated with rat expressed sequencesQuantitative and qualitative proteome characteristics extracted from in-depth integrated genomics and proteomics analysisIsolation of deletion alleles by G4 DNA-induced mutagenesis.Next-generation sequencing approaches in genetic rodent model systems to study functional effects of human genetic variation.ALK2 mutation in a patient with Down's syndrome and a congenital heart defectComparing genome-wide chromatin profiles using ChIP-chip or ChIP-seqEfficient double fragmentation ChIP-seq provides nucleotide resolution protein-DNA binding profilesCombined sequence-based and genetic mapping analysis of complex traits in outbred ratsTranscription factor achaete scute-like 2 controls intestinal stem cell fate.Systematic biases in DNA copy number originate from isolation proceduresConstitutional chromothripsis rearrangements involve clustered double-stranded DNA breaks and nonhomologous repair mechanismsA genome-wide SNP panel for mapping and association studies in the rat.Haplotype block structure is conserved across mammalsMutagenic capacity of endogenous G4 DNA underlies genome instability in FANCJ-defective C. elegans.Identification of a rat model for usher syndrome type 1B by N-ethyl-N-nitrosourea mutagenesis-driven forward geneticsSystematic generation of in vivo G protein-coupled receptor mutants in the ratImproving mammalian genome scaffolding using large insert mate-pair next-generation sequencingGenome-wide pattern of TCF7L2/TCF4 chromatin occupancy in colorectal cancer cells.