1f935123-2841-4f4a-9683-6314ee593630
Establishment of human fetal hepatocyte organoids and CRISPR-Cas9-based gene knockin and knockout in organoid cultures from human liverTroy/Tnfrsf19 marks epidermal cells that govern interfollicular epidermal renewal and cornificationVisceral endoderm induces specification of cardiomyocytes in miceReal time monitoring of BMP Smads transcriptional activity during mouse development.KeyGenes, a Tool to Probe Tissue Differentiation Using a Human Fetal Transcriptional AtlasDNA methylation and transcriptional trajectories during human development and reprogramming of isogenic pluripotent stem cellsCdx2 contributes to the expansion of the early primordial germ cell population in the mouseStrand-specific single-cell methylomics reveals distinct modes of DNA demethylation dynamics during early mammalian developmentEngineered human hepatocyte organoids enable CRISPR-based target discovery and drug screening for steatosisThe need for a standard for informed consent for collection of human fetal materialOrganoid models of fibrolamellar carcinoma mutations reveal hepatocyte transdifferentiation through cooperative BAP1 and PRKAR2A lossLong-Term Expansion of Functional Mouse and Human Hepatocytes as 3D OrganoidsHuman iPSC-Derived Retinas Recapitulate the Fetal CRB1 CRB2 Complex Formation and Demonstrate that Photoreceptors and Müller Glia Are Targets of AAV5Parental haplotype-specific single-cell transcriptomics reveal incomplete epigenetic reprogramming in human female germ cellsDevelopment of Plasmodium falciparum liver-stages in hepatocytes derived from human fetal liver organoid culturesOne-step generation of tumor models by base editor multiplexing in adult stem cell-derived organoidsFast and efficient generation of knock-in human organoids using homology-independent CRISPR-Cas9 precision genome editingDNA Methylation Landscapes of Human Fetal Development