1c89f54f-aaf8-4289-b254-42a4843a93de
Optimization of adeno-associated viral vector-mediated transduction of the corticospinal tractLong-term proteasome dysfunction in the mouse brain by expression of aberrant ubiquitin.CERTL reduces C16 ceramide, amyloid-β levels, and inflammation in a model of Alzheimer's diseaseAlzheimer-associated mutant ubiquitin impairs spatial reference memory.Repulsive guidance molecule a (RGMa) induces neuropathological and behavioral changes that closely resemble Parkinson's diseaseSmall Scale Production of Recombinant Adeno-Associated Viral Vectors for Gene Delivery to the Nervous SystemCharacterization of an immune-evading doxycycline-inducible lentiviral vector for gene therapy in the spinal cordMutant ubiquitin decreases amyloid beta plaque formation in a transgenic mouse model of Alzheimer's disease.Modest proteasomal inhibition by aberrant ubiquitin exacerbates aggregate formation in a Huntington disease mouse model.Expression of a Mutant SEMA3A Protein with Diminished Signalling Capacity Does Not Alter ALS-Related Motor Decline, or Confer Changes in NMJ Plasticity after BotoxA-Induced Paralysis of Male Gastrocnemic MuscleLow levels of mutant ubiquitin are degraded by the proteasome in vivo.