0c9cf992-3c3d-47fe-a0cb-2f2427bab2f1
Targeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screeningDrug-repurposing screen on patient-derived organoids identifies therapy-induced vulnerability in KRAS-mutant colon cancerSequential cancer mutations in cultured human intestinal stem cellsLgr5 marks cycling, yet long-lived, hair follicle stem cells.Chromosomal copy number heterogeneity predicts survival rates across cancersAduld Stem Cells in MiceIntestinal RegenerationPatient-Derived Ovarian Cancer Organoids Mimic Clinical Response and Exhibit Heterogeneous Inter- and Intrapatient Drug ResponsesAn organoid platform for ovarian cancer captures intra- and interpatient heterogeneityLgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitroLive imaging of cell division in 3D stem-cell organoid culturesBiased competition between Lgr5 intestinal stem cells driven by oncogenic mutation induces clonal expansionSingle Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche.Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomasLgr6 marks stem cells in the hair follicle that generate all cell lineages of the skinPaneth cells constitute the niche for Lgr5 stem cells in intestinal cryptsAmplification of progenitors in the mammalian telencephalon includes a new radial glial cell typeReconstructing single-cell karyotype alterations in colorectal cancer identifies punctuated and gradual diversification patternsThe gut microbiota keeps enteric glial cells on the move; prospective roles of the gut epithelium and immune systemTracking adult stem cellsSnake Venom Gland OrganoidsIntestinal crypt homeostasis revealed at single-stem-cell level by in vivo live imagingMicrobiota controls the homeostasis of glial cells in the gut lamina propriaIntestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cellsLive imaging of astrocyte responses to acute injury reveals selective juxtavascular proliferationIn Vivo Imaging Reveals Existence of Crypt Fission and Fusion in Adult Mouse IntestineSlide preparation for single-cell-resolution imaging of fluorescent proteins in their three-dimensional near-native environmentHigh-resolution 3D imaging of fixed and cleared organoidsOngoing chromosomal instability and karyotype evolution in human colorectal cancer organoidsProminin-1/CD133 marks stem cells and early progenitors in mouse small intestine.