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Oral mucosal organoids as a potential platform for personalized cancer therapySequential cancer mutations in cultured human intestinal stem cellsGenomic and Functional Overlap between Somatic and Germline Chromosomal RearrangementsA Living Biobank of Breast Cancer Organoids Captures Disease HeterogeneityLong-term expanding human airway organoids for disease modelingPatient-derived organoids model cervical tissue dynamics and viral oncogenesis in cervical cancerEstablishment, Maintenance, Differentiation, Genetic Manipulation, and Transplantation of Mouse and Human Lacrimal Gland OrganoidsAdult mouse and human organoids derived from thyroid follicular cells and modeling of Graves' hyperthyroidismAn organoid platform for ovarian cancer captures intra- and interpatient heterogeneityUnbiased transcription factor CRISPR screen identifies ZNF800 as master repressor of enteroendocrine differentiationGeneration of an inducible colon-specific Cre enzyme mouse line for colon cancer researchLoss of sdhb in zebrafish larvae recapitulates human paraganglioma characteristicsMouse and human urothelial cancer organoidsLarge-scale identification of coregulated enhancer networks in the adult human brainEpiblast inducers capture mouse trophectoderm stem cells in vitro and pattern blastoids for implantation in uteroBlastocyst-like structures generated solely from stem cellsEnteroendocrine and tuft cells support Lgr5 stem cells on Paneth cell depletionReplacement of Lost Lgr5-Positive Stem Cells through Plasticity of Their Enterocyte-Lineage DaughtersExploring the human lacrimal gland using organoids and single-cell sequencingDruggable growth dependencies and tumor evolution analysis in patient-derived organoids of neuroendocrine neoplasms from multiple body sitesLong-Term Expansion of Functional Mouse and Human Hepatocytes as 3D OrganoidsIdentification of stem cells in small intestine and colon by marker gene Lgr5Snake Venom Gland OrganoidsAssessing the origin of high-grade serous ovarian cancer using CRISPR-modification of mouse organoidsMapping early fate determination in Lgr5+ crypt stem cells using a novel Ki67-RFP alleleVisualization of a short-range Wnt gradient in the intestinal stem-cell nicheModelling of primary ciliary dyskinesia using patient-derived airway organoidsCorrection
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Jeroen Korving