Caught up in a Wnt storm: Wnt signaling in cancerMutations in the APC tumor suppressor gene cause chromosomal instability in colorectal cancerYou Wnt some, you lose some: oncogenes in the Wnt signaling pathway.Curr OpinThe many faces of the tumor suppressor gene APCNotch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells.Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressorNotch and Wnt inhibitors as potential new drugs for intestinal neoplastic disease.Wnt signalling induces maturation of Paneth cells in intestinal crypts.
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J.H. van Es