Beta- catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinBMapping the consequence of Notch1 proteolysis in vivo with NIP-CRE.Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells.Adenomatous polyposis coli-deficient zebrafish are susceptible to digestive tract neoplasia.The beta catenin/TCF4 complex imposes a crypt progenitor phenotype on colorectal cancer cellsWnt signalling induces maturation of Paneth cells in intestinal crypts.De novo crypt formation and Juvenile Polyposis upon BMP inhibition
author
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M. van den Born
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M. van den