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Long-term proteasome dysfunction in the mouse brain by expression of aberrant ubiquitin.Intermediate filament transcription in astrocytes is repressed by proteasome inhibition.Molecular misreading: a new type of transcript mutation expressed during agingEstrogen receptor alpha and its splice variants in the hippocampus in aging and Alzheimer's disease.Estrogen receptor-alpha splice variants in the medial mamillary nucleus of Alzheimer's disease patients: identification of a novel MB1 isoform.Alzheimer-associated mutant ubiquitin impairs spatial reference memory.A direct androgenic involvement in the expression of human corticotropin-releasing hormone.Mutant ubiquitin decreases amyloid beta plaque formation in a transgenic mouse model of Alzheimer's disease.Modest proteasomal inhibition by aberrant ubiquitin exacerbates aggregate formation in a Huntington disease mouse model.Mutant ubiquitin expressed in Alzheimer's disease causes neuronal deathPineal clock gene oscillation is disturbed in Alzheimer's disease, due to functional disconnection from the "master clock".Molecular changes underlying reduced Pineal Melatonin levels in Alzheimer's disease; Alterations in Preclinical and Clinical StagesLow levels of mutant ubiquitin are degraded by the proteasome in vivo.
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D.F. Fischer