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Targeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screeningDrug-repurposing screen on patient-derived organoids identifies therapy-induced vulnerability in KRAS-mutant colon cancerSequential cancer mutations in cultured human intestinal stem cellsA turquoise fluorescence lifetime-based biosensor for quantitative imaging of intracellular calciumAn organoid platform for ovarian cancer captures intra- and interpatient heterogeneityLive imaging of cell division in 3D stem-cell organoid culturesPhosphatidylinositol-3 kinase signaling controls survival and stemness of hematopoietic stem and progenitor cellsHigh-Resolution mRNA and Secretome Atlas of Human Enteroendocrine CellsReconstructing single-cell karyotype alterations in colorectal cancer identifies punctuated and gradual diversification patternsZebrafish enpp1 mutants exhibit pathological mineralization, mimicking features of generalized arterial calcification of infancy (GACI) and pseudoxanthoma elasticum (PXE)A Biosensor for the Mitotic Kinase MPS1 Reveals Spatiotemporal Activity Dynamics and RegulationOngoing chromosomal instability and karyotype evolution in human colorectal cancer organoids
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Bas Ponsioen