The ets-domain transcription factor Spdef promotes maturation of goblet and paneth cells in the intestinal epithelium.Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitroLgr5 homologues associate with Wnt receptors and mediate R-spondin signallingSingle Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche.Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epitheliumPeyer's patch M cells derived from Lgr5(+) stem cells require SpiB and are induced by RankL in cultured "miniguts"Lgr5(+ve) stem/progenitor cells contribute to nephron formation during kidney developmentTranscription factor achaete scute-like 2 controls intestinal stem cell fate.A critical role for the Wnt effector Tcf4 in adult intestinal homeostatic self-renewal