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Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progenyIntestinal Inflammation and Dysregulated Immunity in Patients With Inherited Caspase-8 DeficiencyGeneration of an inducible colon-specific Cre enzyme mouse line for colon cancer researchPaneth cell extrusion and release of antimicrobial products is directly controlled by immune cell-derived IFN-γHuman intestinal tissue with adult stem cell properties derived from pluripotent stem cellsReplacement of Lost Lgr5-Positive Stem Cells through Plasticity of Their Enterocyte-Lineage DaughtersImmune deficiency-related enteropathy-lymphocytopenia-alopecia syndrome results from tetratricopeptide repeat domain 7A deficiencyConformation-specific inhibitors of activated Ras GTPases reveal limited Ras dependency of patient-derived cancer organoidsFunctional and spatial proteomics profiling reveals intra- and intercellular signaling crosstalk in colorectal cancerGeneration of L cells in mouse and human small intestine organoidsTTC7A mutations disrupt intestinal epithelial apicobasal polarityPlasticity within stem cell hierarchies in mammalian epitheliaGermline deletions in the tumour suppressor gene FOCAD are associated with polyposis and colorectal cancer developmentVisualization of a short-range Wnt gradient in the intestinal stem-cell niche
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Henner F Farin