b5988011-40ea-42d1-9c04-85a3fc789c6e
Reuniting philosophy and science to advance cancer researchDNA damage triggers squamous metaplasia in human lung and mammary cells via mitotic checkpointsTemporal morphogen gradient-driven neural induction shapes single expanded neuroepithelium brain organoids with enhanced cortical identityAtypical teratoid/rhabdoid tumoroids reveal subgroup-specific drug vulnerabilitiesEngineered human hepatocyte organoids enable CRISPR-based target discovery and drug screening for steatosisOrganoid models of fibrolamellar carcinoma mutations reveal hepatocyte transdifferentiation through cooperative BAP1 and PRKAR2A lossHuman airway and nasal organoids reveal escalating replicative fitness of SARS-CoV-2 emerging variantsPatient-derived tumor organoids predict responses to irinotecan-based neoadjuvant chemoradiotherapy in patients with locally advanced rectal cancerDevelopment of Plasmodium falciparum liver-stages in hepatocytes derived from human fetal liver organoid cultures