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Drug-repurposing screen on patient-derived organoids identifies therapy-induced vulnerability in KRAS-mutant colon cancerEvolution-Informed Discovery of the Naphthalenone Biosynthetic Pathway in FungiSMARCB1 loss activates patient-specific distal oncogenic enhancers in malignant rhabdoid tumorsEpigenetic State Changes Underlie Metabolic Switch in Mouse Post-Infarction Border Zone CardiomyocytesThe zebrafish cohesin protein Sgo1 is required for cardiac function and eye developmentA Heterozygous Mutation in Cardiac Troponin T Promotes Ca2+ Dysregulation and Adult Cardiomyopathy in ZebrafishEpigenetic Analyses of Human Left Atrial Tissue Identifies Gene Networks Underlying Atrial FibrillationPrecisely timed regulation of enhancer activity defines the binary expression pattern of Fushi tarazu in the Drosophila embryoAssessment of the Most Optimal Control Tissue for Intracranial Aneurysm Gene Expression StudiesCurrent challenges in understanding the role of enhancers in diseaseModeling (not so) rare developmental disorders associated with mutations in the protein-tyrosine phosphatase SHP2Elevated enhancer-oncogene contacts and higher oncogene expression levels by recurrent CTCF inactivating mutations in acute T cell leukemiaApplication of human liver organoids as a patient-derived primary model for HBV infection and related hepatocellular carcinomaThe centriolar satellite protein Cfap53 facilitates formation of the zygotic microtubule organizing center in the zebrafish embryoSingle-cell genome sequencing of human neurons identifies somatic point mutation and indel enrichment in regulatory elementsXPF-ERCC1 protects liver, kidney and blood homeostasis outside the canonical excision repair pathwaysHow chromosome topologies get their shape
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