Targeted ablation of Crb1 and Crb2 in retinal progenitor cells mimics Leber Congenital Amaurosis.MPP3 regulates levels of PALS1 and adhesion betweenphotoreceptors and Muller cells.MPP3 is required for maintenance of the apical junctional complex, neuronal migration and stratification in the developing cortex.
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J.J. Dudok