11ddab14bd6c4b4ca142f015de8a76b232e4ecaada074b839cac2f57148aa583381f85090c36466eabfb621b80a068e241f478da37ac40ed83b3571853ff6fb86351cd8fa1a446d4a03f58aac8b5b44a6e3a91cf575e43da891bdea69794ecba972cb91a6ed94816a061d0b9e5e53cedabb604b356e1478a811ce3120f55f21eadb829e0ed794e6b9ba99e7c12824f23be687e7ec1534093bf2c495e103374a3de03815f022f45c294097036451d907cdfa075e5f6bb4f499e02fc773222cc1de0a92cc02dfe4d1a923565dad2e747b3
agent
Zebrafish with mutations in mismatch repair genes develop neurofibromas and other tumors.CCBE1 is essential for mammalian lymphatic vascular development and enhances the lymphangiogenic effect of vascular endothelial growth factor-C in vivoThe ets-domain transcription factor Spdef promotes maturation of goblet and paneth cells in the intestinal epithelium.Mapping the consequence of Notch1 proteolysis in vivo with NIP-CRE.Dll1+ secretory progenitor cells revert to stem cells upon crypt damageLack of DNA mismatch repair protein MSH6 in the rat results in hereditary non-polyposis colorectal cancer-like tumorigenesis.T-cell factor 4 (tcf7l2) is the main effector of Wnt signaling during zebrafish intestine organogenesis.Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitroThe leukemia-associated Mllt10/Af10-Dot1l are Tcf4/beta-catenin coactivators essential for intestinal homeostasisZebrafish mutants in the von Hippel-Lindau tumor suppressor display a hypoxic response and recapitulate key aspects of Chuvash polycythemiavon Hippel-Lindau tumor suppressor mutants faithfully model pathological hypoxia-driven angiogenesis and vascular retinopathies in zebrafishA critical role for the Wnt effector Tcf4 in adult intestinal homeostatic self-renewalThe Wnt/beta-catenin pathway regulates cardiac valve formation
author
type
label
J. Korving