Unraveling the ubiquitin-regulated signaling networks by mass spectrometry-based proteomicsCoupled activation and degradation of eEF2K regulates protein synthesis in response to genotoxic stressControl of Epithelial Cell Migration and Invasion by the IKKbeta- and CK1alpha-Mediated Degradation of RAPGEF2Lgr5 homologues associate with Wnt receptors and mediate R-spondin signallingQuantitative and qualitative proteome characteristics extracted from in-depth integrated genomics and proteomics analysisTumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptorsWnt signaling through inhibition of beta-catenin degradation in an intact Axin1 complex