The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markersLgr5 homologues associate with Wnt receptors and mediate R-spondin signallingDifferentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epitheliumER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein responseFunctional Repair of CFTR by CRISPR/Cas9 in Intestinal Stem Cell Organoids of Cystic Fibrosis PatientsGeneration of BAC Transgenic Epithelial OrganoidsControlled gene expression in primary Lgr5 organoid culturesA critical role for the Wnt effector Tcf4 in adult intestinal homeostatic self-renewalTumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors