63107bfd-8262-4708-9b06-13b255fed715
Establishment of human fetal hepatocyte organoids and CRISPR-Cas9-based gene knockin and knockout in organoid cultures from human liverFunctional patient-derived organoid screenings identify MCLA-158 as a therapeutic EGFR × LGR5 bispecific antibody with efficacy in epithelial tumorsCRISPR-Cas Tools and Their Application in Genetic Engineering of Human Stem Cells and OrganoidsA Human Organoid Model of Aggressive Hepatoblastoma for Disease Modeling and Drug TestingOrganoid cultures of early-onset colorectal cancers reveal distinct and rare genetic profilesDifferentiated human airway organoids to assess infectivity of emerging influenza virusUnbiased transcription factor CRISPR screen identifies ZNF800 as master repressor of enteroendocrine differentiationTemporal morphogen gradient-driven neural induction shapes single expanded neuroepithelium brain organoids with enhanced cortical identityPrimary Intestinal Epithelial Organoid CultureFasting-mimicking diet and hormone therapy induce breast cancer regressionEngineered human hepatocyte organoids enable CRISPR-based target discovery and drug screening for steatosisDirected Differentiation of Murine and Human Small Intestinal Organoids Toward All Mature LineagesOrganoid models of fibrolamellar carcinoma mutations reveal hepatocyte transdifferentiation through cooperative BAP1 and PRKAR2A lossLong-Term Expansion of Functional Mouse and Human Hepatocytes as 3D OrganoidsEstablishment and Culture of Human Intestinal Organoids Derived from Adult Stem CellsWnt/β-Catenin Signaling, Disease, and Emerging Therapeutic ModalitiesHuman gastrointestinal epithelia of the esophagus, stomach, and duodenum resolved at single-cell resolutionPersonalized Proteome Profiles of Healthy and Tumor Human Colon Organoids Reveal Both Individual Diversity and Basic Features of Colorectal CancerMolecular characterization of Barrett's esophagus at single-cell resolutionFast and efficient generation of knock-in human organoids using homology-independent CRISPR-Cas9 precision genome editing
externalOrganisations
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