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Oral mucosal organoids as a potential platform for personalized cancer therapyCorrection for Muncan et al., "Rapid Loss of Intestinal Crypts upon Conditional Deletion of the Wnt/Tcf-4 Target Gene c-"Drug-repurposing screen on patient-derived organoids identifies therapy-induced vulnerability in KRAS-mutant colon cancerSequential cancer mutations in cultured human intestinal stem cellsA Living Biobank of Breast Cancer Organoids Captures Disease HeterogeneityLong-term expanding human airway organoids for disease modelingPatient-derived organoids model cervical tissue dynamics and viral oncogenesis in cervical cancerIn vitro expansion of human gastric epithelial stem cells and their responses to bacterial infectionEstablishment, Maintenance, Differentiation, Genetic Manipulation, and Transplantation of Mouse and Human Lacrimal Gland OrganoidsAdult mouse and human organoids derived from thyroid follicular cells and modeling of Graves' hyperthyroidismAn organoid platform for ovarian cancer captures intra- and interpatient heterogeneityUnbiased transcription factor CRISPR screen identifies ZNF800 as master repressor of enteroendocrine differentiationGenetic dissection of colorectal cancer progression by orthotopic transplantation of engineered cancer organoidsGeneration of an inducible colon-specific Cre enzyme mouse line for colon cancer researchPatient-derived pancreatic tumour organoids identify therapeutic responses to oncolytic adenovirusesOptimized human intestinal organoid model reveals interleukin-22-dependency of paneth cell formationReg4+ deep crypt secretory cells function as epithelial niche for Lgr5+ stem cells in colonMouse and human urothelial cancer organoidsHigh-Resolution mRNA and Secretome Atlas of Human Enteroendocrine CellsReplacement of Lost Lgr5-Positive Stem Cells through Plasticity of Their Enterocyte-Lineage DaughtersGeneration and characterization of rat liver stem cell lines and their engraftment in a rat model of liver failureBMP gradient along the intestinal villus axis controls zonated enterocyte and goblet cell statesAn inducible mouse model for microvillus inclusion disease reveals a role for myosin Vb in apical and basolateral traffickingExploring the human lacrimal gland using organoids and single-cell sequencingDruggable growth dependencies and tumor evolution analysis in patient-derived organoids of neuroendocrine neoplasms from multiple body sitesLong-Term Expansion of Functional Mouse and Human Hepatocytes as 3D OrganoidsIdentification of stem cells in small intestine and colon by marker gene Lgr5Lipid-mediated Wnt protein stabilization enables serum-free culture of human organ stem cellsSnake Venom Gland OrganoidsAssessing the origin of high-grade serous ovarian cancer using CRISPR-modification of mouse organoidsPatient-derived head and neck cancer organoids allow treatment stratification and serve as a tool for biomarker validation and identificationHuman gastrointestinal epithelia of the esophagus, stomach, and duodenum resolved at single-cell resolutionOne-step generation of tumor models by base editor multiplexing in adult stem cell-derived organoidsAn organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneityIdentification of multipotent luminal progenitor cells in human prostate organoid culturesModelling of primary ciliary dyskinesia using patient-derived airway organoidsCorrection
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Harry Begthel