501aee2d-c5c8-4420-9a75-b98b84b5b8d4
Reuniting philosophy and science to advance cancer researchUncovering the mode of action of engineered T cells in patient cancer organoidsSIRT1 inhibitors mitigate radiation-induced GI syndrome by enhancing intestinal-stem-cell survivalDNA damage triggers squamous metaplasia in human lung and mammary cells via mitotic checkpointsThe role of macrophages in non-small cell lung cancer and advancements in 3D co-culturesTemporal morphogen gradient-driven neural induction shapes single expanded neuroepithelium brain organoids with enhanced cortical identityAtypical teratoid/rhabdoid tumoroids reveal subgroup-specific drug vulnerabilitiesA tissue-intrinsic IL-33/EGF circuit promotes epithelial regeneration after intestinal injuryEngineered human hepatocyte organoids enable CRISPR-based target discovery and drug screening for steatosisOrganoid models of fibrolamellar carcinoma mutations reveal hepatocyte transdifferentiation through cooperative BAP1 and PRKAR2A lossHuman airway and nasal organoids reveal escalating replicative fitness of SARS-CoV-2 emerging variantsPatient-Derived Organoids from Colorectal Cancer with Paired Liver Metastasis Reveal Tumor Heterogeneity and Predict Response to ChemotherapyHomeostatic mini-intestines through scaffold-guided organoid morphogenesisPatient-derived tumor organoids predict responses to irinotecan-based neoadjuvant chemoradiotherapy in patients with locally advanced rectal cancerDevelopment of Plasmodium falciparum liver-stages in hepatocytes derived from human fetal liver organoid culturesOne-step generation of tumor models by base editor multiplexing in adult stem cell-derived organoidsPhospholamban antisense oligonucleotides improve cardiac function in murine cardiomyopathy
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