p21 loss blocks senescence following Apc loss and provokes tumourigenesis in the renal but not the intestinal epitheliumFocal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signalingRapid loss of intestinal crypts upon conditional deletion of the Wnt/Tcf-4 target gene c-Myc.Cyclin D1 is not an immediate target of beta-catenin following Apc loss in the intestine.Myc deletion rescues Apc deficiency in the small intestineCrypt stem cells as the cells-of-origin of intestinal cancer.Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migrationCyclin D2-cyclin-dependent kinase 4/6 is required for efficient proliferation and tumorigenesis following Apc lossInactivation of Apc perturbs mammary development, but only directly results in acanthoma in the context of Tcf-1 deficiency
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A.R. Clarke