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Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancerIntra-tumour diversification in colorectal cancer at the single-cell levelSingle-cell messenger RNA sequencing reveals rare intestinal cell typesTissue-specific mutation accumulation in human adult stem cells during lifeReg4+ deep crypt secretory cells function as epithelial niche for Lgr5+ stem cells in colonEnteroendocrine and tuft cells support Lgr5 stem cells on Paneth cell depletionStudying cellular heterogeneity and drug sensitivity in colorectal cancer using organoid technologyLong-term culture of genome-stable bipotent stem cells from adult human liverOngoing chromosomal instability and karyotype evolution in human colorectal cancer organoidsAutomated brightfield morphometry of 3D organoid populations by OrganoSegDefining the Identity and Dynamics of Adult Gastric Isthmus Stem Cells
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Nobuo Sasaki