Significance of the White Sea as stopover for Bewick's Swans Cygnus columbianus bewickii in springChromothripsis as a mechanism driving complex de novo structural rearrangements in the germlineIncomplete segregation of MYH11 variants with thoracic aortic aneurysms and dissections and patent ductus arteriosusDiscovery of variants unmasked by hemizygous deletionsConstitutional chromothripsis rearrangements involve clustered double-stranded DNA breaks and nonhomologous repair mechanisms