Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancerMET Signaling Overcomes Epidermal Growth Factor Receptor Inhibition in Normal and Colorectal Cancer Stem Cells Causing Drug ResistanceOncogene-inducible organoids as a miniature platform to assess cancer characteristicsPrimary Intestinal Epithelial Organoid CultureKSR1- and ERK-dependent translational regulation of the epithelial-to-mesenchymal transition5-FU promotes stemness of colorectal cancer via p53-mediated WNT/β-catenin pathway activationThree-dimensional single-cell imaging for the analysis of RNA and protein expression in intact tumour biopsiesMutational signature in colorectal cancer caused by genotoxic pks+ E. coli
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Tomohiro Mizutani