Wnt signaling, lgr5, and stem cells in the intestine and skin.Lgr5 homologues associate with Wnt receptors and mediate R-spondin signallingLoss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of DvlOLFM4 is a robust marker for stem cells in human intestine and marks a subset of colorectal cancer cells.The Intestinal Wnt/TCF SignatureLgr6 marks stem cells in the hair follicle that generate all cell lineages of the skinDiabetes Risk Gene and Wnt Effector Tcf7l2/TCF4 Controls Hepatic Response to Perinatal and Adult Metabolic DemandTranscription factor achaete scute-like 2 controls intestinal stem cell fate.A critical role for the Wnt effector Tcf4 in adult intestinal homeostatic self-renewal
author
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A. Haegebarth
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Haegebarth