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Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancerTargeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screeningSequential cancer mutations in cultured human intestinal stem cellsOrganoid culture systems for prostate epithelial and cancer tissueTranslational applications of adult stem cell-derived organoidsOncogenic signaling is coupled to colorectal cancer cell differentiation stateSMARCB1 loss activates patient-specific distal oncogenic enhancers in malignant rhabdoid tumorsUnbiased transcription factor CRISPR screen identifies ZNF800 as master repressor of enteroendocrine differentiationOrganoids in cancer researchTubuloids derived from human adult kidney and urine for personalized disease modelingXenograft and organoid model systems in cancer researchGenetic dissection of colorectal cancer progression by orthotopic transplantation of engineered cancer organoidsAtypical teratoid/rhabdoid tumoroids reveal subgroup-specific drug vulnerabilitiesThe Generation of Organoids for Studying Wnt SignalingProfiling proliferative cells and their progeny in damaged murine heartsTGFβ signaling directs serrated adenomas to the mesenchymal colorectal cancer subtypeRewiring glucose metabolism improves 5-FU efficacy in p53-deficient/KRASG12D glycolytic colorectal tumorsNext-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In VivoWho Is in the Driver's SeatAn organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneityIdentification of multipotent luminal progenitor cells in human prostate organoid cultures
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Jarno Drost