Chondroitinase ABC promotes plasticity of spinal reflexes following peripheral nerve injury.Recent advances in the therapeutic uses of chondroitinase ABCIntegrin activation or alpha9 expression allows retinal pigmented epithelial cell adhesion on Bruch's membrane in wet age-related macular degeneration.Lentiviral vectors express chondroitinase ABC in cortical projections and promote sprouting in injured corticospinal axons.The chemorepulsive axon guidance protein semaphorin 3A is a constituent of perineuronal nets in the adult rodent brain.alpha9 Integrin promotes neurite outgrowth on tenascin-C and enhances sensory axon regeneration.Semaphorin 3A binds to the perineuronal nets via chondroitin sulfate type E motifs in rodents brains.Integrins promote axonal regeneration after injury of the nervous system
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J.W. Fawcett