2809fa62-cf17-40cf-b9ac-6ee5fbd9c61a
Reuniting philosophy and science to advance cancer researchDrug-repurposing screen on patient-derived organoids identifies therapy-induced vulnerability in KRAS-mutant colon cancerG-quadruplex resolutionUncovering the mode of action of engineered T cells in patient cancer organoidsDesmosomal protein degradation as an underlying cause of arrhythmogenic cardiomyopathyOncogenic signaling is coupled to colorectal cancer cell differentiation stateSMARCB1 loss activates patient-specific distal oncogenic enhancers in malignant rhabdoid tumorsA cyclin-dependent kinase-mediated phosphorylation switch of disordered protein condensationSelf-organizing models of human trunk organogenesis recapitulate spinal cord and spine co-morphogenesisDNA damage triggers squamous metaplasia in human lung and mammary cells via mitotic checkpointsUnbiased transcription factor CRISPR screen identifies ZNF800 as master repressor of enteroendocrine differentiationZero-Mode Waveguide Nanowells for Single-Molecule Detection in Living CellsCombinatorial single-cell profiling of major chromatin types with MAbIDDruggable redox pathways against Mycobacterium abscessus in cystic fibrosis patient-derived airway organoidsNanoblades allow high-level genome editing in murine and human organoidsTemporal morphogen gradient-driven neural induction shapes single expanded neuroepithelium brain organoids with enhanced cortical identityLymphatic Invasion of Plakoglobin-Dependent Tumor Cell Clusters Drives Formation of Polyclonal Lung Metastases in Colon CancerOrganoid cell fate dynamics in space and timeArtificial intelligence for natural product drug discoveryDual targeting of cancer metabolome and stress antigens affects transcriptomic heterogeneity and efficacy of engineered T cellsPharmaco-proteogenomic characterization of liver cancer organoids for precision oncologyAtypical teratoid/rhabdoid tumoroids reveal subgroup-specific drug vulnerabilitiesSARS-CoV-2 Omicron entry is type II transmembrane serine protease-mediated in human airway and intestinal organoid modelsPermission to passBRCA2-HSF2BP oligomeric ring disassembly by BRME1 promotes homologous recombinationEngineered human hepatocyte organoids enable CRISPR-based target discovery and drug screening for steatosisDirected Differentiation of Murine and Human Small Intestinal Organoids Toward All Mature LineagesOrganoid models of fibrolamellar carcinoma mutations reveal hepatocyte transdifferentiation through cooperative BAP1 and PRKAR2A lossEfficient Synthesis of DNA Duplexes Containing Reduced Acetaldehyde Interstrand Cross-LinksHuman airway and nasal organoids reveal escalating replicative fitness of SARS-CoV-2 emerging variantsPaecilomycone Inhibits Quorum Sensing in Gram-Negative BacteriaElevated enhancer-oncogene contacts and higher oncogene expression levels by recurrent CTCF inactivating mutations in acute T cell leukemiaA living biobank of matched pairs of patient-derived xenografts and organoids for cancer pharmacologyPGE2 alters chromatin through H2A.Z-variant enhancer nucleosome modification to promote hematopoietic stem cell fateTranscriptomic profile comparison reveals conservation of ionocytes across multiple organsPrinciples and dynamics of spindle assembly checkpoint signallingPatient-derived head and neck cancer organoids allow treatment stratification and serve as a tool for biomarker validation and identificationLoss of LGR4/GPR48 causes severe neonatal salt wasting due to disrupted WNT signaling altering adrenal zonationDevelopment of Plasmodium falciparum liver-stages in hepatocytes derived from human fetal liver organoid culturesOne-step generation of tumor models by base editor multiplexing in adult stem cell-derived organoids
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