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Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancerOral mucosal organoids as a potential platform for personalized cancer therapySequential cancer mutations in cultured human intestinal stem cellsA Living Biobank of Breast Cancer Organoids Captures Disease HeterogeneityPatient-derived organoids model cervical tissue dynamics and viral oncogenesis in cervical cancerProbing the Tumor Suppressor Function of BAP1 in CRISPR-Engineered Human Liver OrganoidsSister chromatid exchanges induced by perturbed replication can form independently of BRCA1, BRCA2 and RAD51Tubuloids derived from human adult kidney and urine for personalized disease modelingGenetic dissection of colorectal cancer progression by orthotopic transplantation of engineered cancer organoidsColon Tumors in Enterotoxigenic Bacteroides fragilis (ETBF)-Colonized Mice Do Not Display a Unique Mutational Signature but Instead Possess Host-Dependent Alterations in the APC GeneTissue-specific mutation accumulation in human adult stem cells during lifeTranscriptomic and Epigenomic Profiling of Histone Deacetylase Inhibitor Treatment Reveals Distinct Gene Regulation Profiles Leading to Impaired Neutrophil DevelopmentEvaluating CRISPR-based prime editing for cancer modeling and CFTR repair in organoidsGenome sequencing of normal cells reveals developmental lineages and mutational processesGenomic landscape of rat strain and substrain variationCRISPR-Based Adenine Editors Correct Nonsense Mutations in a Cystic Fibrosis Organoid BiobankOrganoid models of human and mouse ductal pancreatic cancerTroy/TNFRSF19 marks epithelial progenitor cells during mouse kidney development that continue to contribute to turnover in adult kidneyOne-step generation of tumor models by base editor multiplexing in adult stem cell-derived organoidsMolecular characterization of Barrett's esophagus at single-cell resolutionLong-term culture of genome-stable bipotent stem cells from adult human liverAn organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneityMutational signature in colorectal cancer caused by genotoxic pks+ E. coliMeasuring mutation accumulation in single human adult stem cells by whole-genome sequencing of organoid culturesIdentification of multipotent luminal progenitor cells in human prostate organoid cultures
author
nationality
type
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Ruben van Boxtel
firstName
lastName
van Boxtel