Targeted ablation of Crb1 and Crb2 in retinal progenitor cells mimics Leber Congenital Amaurosis.Loss of CRB2 in the mouse retina mimics human retinitis pigmentosa due to mutations in the CRB1 gene.PALS1 is essential for retinal pigment epithelium structure and neural retina stratification.Noninvasive, in vivo assessment of mouse retinal structure using optical coherence tomography.