p21 loss blocks senescence following Apc loss and provokes tumourigenesis in the renal but not the intestinal epitheliumFocal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signalingSpindle orientation bias in gut epithelial stem cell compartments is lost in precancerous tissueCrypt stem cells as the cells-of-origin of intestinal cancer.Cyclin D2-cyclin-dependent kinase 4/6 is required for efficient proliferation and tumorigenesis following Apc loss
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R.A. Ridgway