Expansion of Adult Human Pancreatic Tissue Yields Organoids Harboring Progenitor Cells with Endocrine Differentiation PotentialTacrolimus-Induced BMP/SMAD Signaling Associates with Metabolic Stress-Activated FOXO1 to Trigger β-Cell FailureGlomerular Function and Structural Integrity Depend on Hyaluronan Synthesis by Glomerular EndotheliumPancreatic α-cell mass in obesityOxidative Stress Leads to β-Cell Dysfunction Through Loss of β-Cell IdentityLoss of β-cell identity occurs in type 2 diabetes and is associated with islet amyloid depositsHighly efficient ex vivo lentiviral transduction of primary human pancreatic exocrine cellsSingle-Cell Transcriptomics Links Loss of Human Pancreatic β-Cell Identity to ER StressLong-term ketogenic diet causes glucose intolerance and reduced β- and α-cell mass but no weight loss in mice
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Ton J Rabelink